Three Australian and two American cancer centers are spearheading the first clinical trial of Cantrixil, Novogen’s therapy to restore ovarian cancer patients’ sensitivity to chemotherapy.
Associate Professor Jim Coward, an oncologist at Icon Cancer Care in South Brisbane, is directing the trial. In addition to Icon, the Australian trial locations are the Flinders Medical Center and Westmead Hospital in Sydney. The trial partners in the United States are the Peggy and Charles Stephenson Cancer Center and the Mary Crowley Cancer Research Center.
A key objective of the Phase 1 trial (NCT02903771), which began enrolling participants in August 2016, is to see if Cantrixil is safe for patients with recurring ovarian cancer. Researchers are administering it once a week through the peritoneum, or abdominal cavity.